Organic dust induced mitochondrial dysfunction could be targeted via cGAS-STING or mitochondrial NOX-2 inhibition
N. Massey, D. Shrestha, S. M. Bhat, N. Kondru, A. Charli, L. A. Karriker, A. Kanthasamy, C. Charavaryamath
This study shows that organic dust exposure increases mitochondrial DNA release and inflammation in microglial cells, which can be mitigated by inhibiting NOX-2 or STING.
Cell and Tissue Research · Mar 9, 2021Peer-reviewedCell Biology