Inhibition of PI3K p110δ activity reduces IgE production in IL-4 and anti-CD40 stimulated human tonsil B cell cultures
A. Cutrina-Pons, A. de Sa, D. J. Fear, H. Gould, F. Ramadani
This study shows that inhibiting PI3K p110δ reduces IgE production in human B cells stimulated with IL-4 and anti-CD40, but not IgG1, and identifies proliferation as the key mechanism.
bioRxiv · Aug 9, 2022Immunology