APOBEC3B reporter myeloma cell lines identify DNA damage response pathways leading to APOBEC3B expression
H. Yamazaki, K. Shirakawa, T. Matsumoto, Y. Kazuma, H. Matsui, Y. Horisawa, E. Stanford, A. D. Sarca, R. Shirakawa, K. Shindo, A. Takaori-Kondo
The paper develops APOBEC3B reporter myeloma cell lines to study DNA damage response pathways that regulate APOBEC3B expression, finding that conventional therapies increase its expression while targeted drugs do not.
bioRxiv · Sep 24, 2019Cancer Biology