The sequestration of miR-642a-3p by a complex formed by HIV-1 Gag and human Dicer increases AFF4 expression and viral production
S. P. Alpuche-Lazcano, O. R. Dunkley, R. J. Scarborough, S. M. Daniels, A. Daher, M. Truchi, M. C. Estable, B. Mari, A. J. Mouland, A. Gatignol
The paper shows HIV-1 Gag sequesters miR-642a-3p with Dicer, increasing AFF4 expression and HIV-1 production by disrupting miR-642a-3p's antiviral activity.
bioRxiv · May 24, 2023 · PreprintMicrobiology