B. Mari

Lineage-tracing of Acta2+ cells in aged mice during lung fibrosis formation and resolution supports the lipofibroblasts to myofibroblast reversible switch

This study traces Acta2+ cells in aged mice during lung fibrosis to show lipofibroblasts can reversibly switch to myofibroblasts, with similar patterns observed in humans.

Aging affects reprogramming of murine pulmonary capillary endothelial cells after lung injury

This study compares transcriptomic changes in pulmonary capillary endothelial cells from young and aged mice after lung injury, finding age-related differences in resolution and fibrotic signatures.

The sequestration of miR-642a-3p by a complex formed by HIV-1 Gag and human Dicer increases AFF4 expression and viral production

The paper shows HIV-1 Gag sequesters miR-642a-3p with Dicer, increasing AFF4 expression and HIV-1 production by disrupting miR-642a-3p's antiviral activity.

Processing body dynamics drive non-genetic MEK inhibitors tolerance by fine-tuning KRAS and NRAS translation

The paper identifies a mechanism where MEK inhibitors induce tolerance by promoting KRAS and NRAS translation via PB dissolution, revealing a dynamic feedback loop in MAPK signaling.

Uveal Melanoma: a miR-16 disease?

This study identifies miR-16's non-canonical role in uveal melanoma by sequestering sponge RNAs, leading to oncogene derepression and poor survival, with a sponge-signature outperforming current methods.

Blockade of pro-fibrotic response mediated by the miR-143/-145 cluster prevents targeted therapy-induced phenotypic plasticity and resistance in melanoma

This study identifies the miR-143/-145 cluster as a driver of therapy-resistant mesenchymal-like phenotype in melanoma and shows that blocking its pro-fibrotic effects enhances MAPK inhibitor efficacy.

Identification of Paired-related Homeobox Protein 1 as a key mesenchymal transcription factor in Idiopathic Pulmonary Fibrosis

This study identifies PRRX1 as a key mesenchymal transcription factor driving lung fibrogenesis in IPF and shows its inhibition reduces fibrotic remodeling.

Identification of oncolytic vaccinia restriction factors in canine high-grade mammary tumor cells using single-cell transcriptomics

This paper uses single-cell transcriptomics to identify DDIT4 as a resistance factor against oncolytic vaccinia virus in canine TNBC cells.

Biophysical forces rewire cell metabolism to guide microtubule-dependent cell mechanics

This study shows mechanical forces rewire glutamine metabolism to promote microtubule glutamylation, affecting cell mechanics and mechanodependent functions.