Synthesis and structural optimization of 2,7,9-trisubstituted purin-8-ones as FLT3-ITD inhibitors
M. Tomanova, K. Kozlanska, R. Jorda, L. Jedinak, T. Havlikova, E. Reznickova, M. Perina, P. Klener, A. Dolnikova, P. Cankar, V. Krystof
The paper designs and evaluates 2,7,9-trisubstituted purin-8-ones as FLT3-ITD inhibitors, identifying compound 15a with improved selectivity and activity in vitro and in vivo.
bioRxiv · Dec 10, 2022Pharmacology & Toxicology