TCF4 trinucleotide repeat expansions and UV irradiation increase susceptibility to ferroptosis in Fuchs endothelial corneal dystrophy
S. Saha, J. M. Skeie, G. A. Schmidt, T. Eggleston, H. Shevalye, C. S. Sales, P. Phruttiwanichakun, A. Dusane, M. Field, T. A. Rinkoski, M. P. Fautsch, K. H. Baratz, M. Roy, A. S. Jun, A. K. Salem, M. A. Greiner
This study shows that TCF4 trinucleotide repeat expansions and UV irradiation increase ferroptosis susceptibility in Fuchs endothelial corneal dystrophy by promoting iron-mediated lipid peroxidation and cell death.
bioRxiv · Jun 27, 2022 · PreprintCell Biology