A. E. Miele

Cellular redox metabolism is modulated by the distinct localization of cyclic nucleotide phosphodiesterase 5A isoforms

The paper investigates how different localization of PDE5A isoforms affects cellular redox metabolism and metabolic switching.

The HIV-1 Integrase C-Terminal domain induces TAR RNA structural changes promoting Tat binding.

This study shows that the HIV-1 Integrase C-terminal domain interacts with TAR RNA, inducing structural changes that facilitate Tat binding and displace IN from TAR.