Novel miRNA-inducing drugs enable differentiation of retinoic acid-resistant neuroblastoma cells
L. D. Nguyen, S. Sengupta, K. I. Cho, A. Floru, R. E. George, A. M. Krichevsky
The paper identifies PP121 and bufalin as drugs that induce differentiation in retinoic acid-resistant neuroblastoma cells through miR-124 activation, maintaining differentiated states for over 16 weeks.
bioRxiv · Jun 5, 2024 · PreprintCancer Biology