S. Sengupta

Novel miRNA-inducing drugs enable differentiation of retinoic acid-resistant neuroblastoma cells

The paper identifies PP121 and bufalin as drugs that induce differentiation in retinoic acid-resistant neuroblastoma cells through miR-124 activation, maintaining differentiated states for over 16 weeks.

Dishevelled localization and function are differentially regulated by structurally distinct sterols

This study shows that different sterols affect DVL2 localization and function through specific structural interactions, impacting cell signaling and homeostasis.

Identification of distinct genotypes in circulating RSV A strains based on variants on the virus replication-associated genes

The paper identifies distinct genotypes in RSV A strains by analyzing variants in replication-associated genes from sequenced samples and highlights the polymerase protein L as a robust genotyping target.

Microbiota-derived inosine programs protective CD8+ T cell responses against influenza in newborns

This study identifies microbiota-derived inosine as a key factor in promoting CD8+ T cell responses against influenza in newborns by reversing epigenetic dysregulation.

Requirement of a Wnt5A-Microbiota Axis in the Maintenance of Gut B Cell Repertoire and Protection from Infection

This study shows that Wnt5A and gut microbiota interact to maintain B cell repertoire and protect against infection, with Wnt5A heterozygous mice showing increased susceptibility to Salmonella.

Early-stage lung adenocarcinoma is driven by an injury-associated, plastic cell state dependent on a KRAS-ITGA3-SRC axis

This study identifies an injury-associated, plastic cell state in early-stage lung adenocarcinoma driven by the KRAS-ITGA3-SRC axis, showing its role in tumor initiation and progression.

Prognostic relevance of correlated co-expression of coding and noncoding RNAs in cervical cancers

The paper identifies prognostically relevant co-expression patterns between coding and noncoding RNAs in HPV16-positive cervical cancers and links them to patient survival.

GABA(A) receptor activation drives GABARAP-Nix mediated autophagy to radiation-sensitize primary and brain-metastatic lung adenocarcinoma tumors

This paper shows that activating GABA(A) receptors in lung cancer cells triggers autophagy via GABARAP-Nix interaction, enhancing radiation sensitivity and reducing toxicity in preclinical models.

Nucleo-cytoplasmic environment modulates spatio-temporal p53 phase separation

This study shows that p53 phase separation and condensate formation are modulated by the nucleo-cytoplasmic environment and cancer-associated mutations affect condensate stability and DNA binding.

Reproductive biology of the mudskippers Boleophthalmus boddarti and Periophthalmus novemradiatus in the Indian Sundarbans

This study investigates the reproductive biology of two mudskipper species in the Indian Sundarbans, reporting growth patterns, maturity sizes, fecundity, and gonad characteristics.

p53 amyloid pathology with cancer grades and p53 mutations

The paper shows p53 amyloid load correlates with cancer grades and shows both mutant and wild-type p53 form amyloids in cancer tissues.

TGF-β1 activates neutrophil signaling and gene expression but not migration

This study shows TGF-β1 activates neutrophil signaling pathways but not migration, and induces gene expression changes in HL-60 cells.

The RNA-DNA world and the emergence of DNA-encoded heritable traits

This study explores the transition from an RNA world to a DNA-encoded heritable world through computational analysis of protocellular evolution with DNA nucleotides.

A diet-independent zebrafish model for NAFLD recapitulates patient lipid profiles and offers a system for small molecule screening

This study develops a diet-independent zebrafish model of NAFLD that mimics patient lipid profiles and demonstrates responsiveness to Rosiglitazone treatment.

Treg cells drive MYCN-mediated immunosuppression and tumor aggressiveness in high-risk neuroblastoma

This study shows Treg cells drive MYCN-mediated immunosuppression and tumor aggressiveness in high-risk neuroblastoma using human and zebrafish models.

Rational engineering of a β-glucosidase (H0HC94) from glycosyl family I (GH1) to improve catalytic performance on cellobiose

This paper rationally engineers a β-glucosidase to enhance its catalytic activity and specificity for cellobiose over pNPGlc.

Wnt5A Signaling Regulates Gut Bacterial Survival and T cell Homeostasis

This study shows that Wnt5A signaling promotes survival of gut commensals and affects T cell balance, highlighting its role in maintaining gut bacterial diversity and immune homeostasis.

The effect of environment on the evolution and proliferation of protocells of increasing complexity

This study develops a computational model to examine how environmental phases affect the evolution and proliferation of complex protocells containing ribozymes.

Circadian Control of Pulmonary Endothelial Signaling occurs via NADPH oxidase 2-NLRP3 pathway

This study shows that circadian rhythms in pulmonary endothelial cells are disrupted by LPS through the NOX2-NLRP3 pathway, leading to sustained inflammation.

DNA damage response signaling is crucial for effective Chikungunya virus replication

This study shows that Chikungunya virus (CHIKV) infection activates DNA damage response (DDR) pathways, increases DNA damage, and interacts with Chk2 and Chk1 to facilitate viral replication and cell cycle arrest.

Non-cancer stem cell-derived Fibromodulin activates Integrin-dependent Notch signaling in endothelial cells to promote tumor angiogenesis and growth

This study shows that Fibromodulin from non-cancer stem cells promotes glioma tumor growth by activating Notch signaling in endothelial cells through integrin-dependent paracrine signaling.

Borrowing ecological theory to infer interactions between sensitive and resistant breast cancer cell populations

The paper uses ecological theory and in-vitro data to infer interactions between resistant and sensitive breast cancer cell populations, finding a net mutualistic interaction and suggesting adaptive treatment strategies.

Inhibition of autophagy as a novel therapy for the treatment of neurofibromatosis type 1 tumors

This study identifies autophagy inhibitors as potential therapies for NF1 tumors by showing their effectiveness in Drosophila and human models.

Phytochrome B regulates reactive oxygen signaling during abiotic and biotic stress in plants

This study shows that phytochrome B regulates reactive oxygen species production during both abiotic and biotic stress in plants, working with RBOH proteins to control stress responses.

Circadian regulation of lung repair and regeneration

This study shows that the circadian clock regulates lung repair and regeneration independently of inflammation, identifies the Wnt/β-catenin pathway as a mediator, and links poor circadian rhythms to worse lung infection outcomes.

Persistent CAD activity in memory CD8+ T cells supports rRNA synthesis and ribosomal biogenesis required at rechallenge

The paper identifies CAD-induced pyrimidine synthesis and ribosomal biogenesis as critical for rapid recall responses in memory CD8+ T cells.

An evolutionary divergent thermodynamic brake in ZAP-70 finetunes the kinetic proofreading in T cell

This study identifies a thermodynamic brake in ZAP-70 that regulates T cell signaling kinetics and ligand selectivity, with evolutionary implications for immune system divergence.

PRMT5 promotes symmetric dimethylation of RNA processing proteins and modulates activated T cell alternative splicing and Ca2+/NFAT signaling

This study identifies PRMT5's role in modulating alternative splicing and Ca2+/NFAT signaling in activated T cells through symmetric dimethylation of RNA processing proteins.

Human Satellite III long non-coding RNA imparts survival benefits to cancer cells

This study shows that SatIII lncRNA promotes cancer cell survival by resisting chemotherapy and is induced in cancer cells independently of heat shock.

Network rewiring promotes cooperation in an aspirational learning model

The paper shows that network rewiring and a low-information learning model can sustain cooperation in a public goods game across a wide range of learning efficiencies.