Expression of neuronal Na+ leak channel, NALCN, provides for persistent invasion of metastasizing cancer cells
O. Iamshanova, D. Gordienko, A. Folcher, A. Bokhobza, G. Shapovalov, D. Kannancheri-Puthooru, P. Mariot, L. Allart, E. Desruelles, C. Spriet, R. Diez, T. Oullier, S. Marionneau-Lambot, L. Brisson, S. Geraci, , N. Prevarskaya
The paper identifies NALCN as a key player in metastatic cancer cell invasion by generating Ca2+ oscillations that drive Src kinase activity and proteolytic enzyme secretion.
bioRxiv · Aug 13, 2020 · PreprintCell Biology