Pinpointing of cysteine oxidation sites in vivo by high-resolution proteomics reveals mechanism of redox-dependent inhibition of STING
N. Zamorano Cuervo, A. Fortin, E. Caron, S. Chartier, N. Grandvaux
This study identifies thousands of reversible Cys oxidation sites in vivo using a bioswitch method and mass spectrometry, revealing redox-dependent inhibition of STING through Cys206 oxidation.
bioRxiv · Mar 25, 2020Immunology