Ionpair-π interactions favor cell penetration of arginine/tryptophan-rich cell-penetrating peptides
A. Walrant, A. Bauza, C. Girardet, I. D. Alves, S. Lecomte, F. Illien, S. Cardon, N. Chaianantakul, M. Pallerla, F. Burlina, A. Frontera, S. Sagan
This study investigates how Trp and facial amphiphilicity affect CPP uptake, finding that Trp enhances uptake in GAG-expressing cells and that facial amphiphilicity is not essential.
bioRxiv · Jul 28, 2019Biochemistry