A. G. Lai

Phylogenetic analysis of TALE superclass homeobox genes in amphipod crustaceans

The paper identifies and phylogenetically analyzes TALE class genes in amphipod crustaceans, revealing six subclasses and providing FASTA sequences.

An integrative pan-cancer investigation reveals common genetic and transcriptional alterations of AMPK pathway genes as important predictors of clinical outcomes across major cancer types

This study identifies common genetic and transcriptional alterations in AMPK pathway genes across cancers and shows their prognostic significance in multiple tumor types.

An immunoevasive strategy through clinically-relevant pan cancer genomic and transcriptomic alterations of JAK-STAT signaling components

This study identifies JAK-STAT pathway genetic alterations across 21 cancer types and links them to survival outcomes and immune features, revealing pan-cancer immunoevasive strategies.

Pan-cancer mutational landscape of the PPAR pathway reveals universal patterns of dysregulated metabolism and interactions with tumor immunity and hypoxia

The paper analyzes PPAR pathway mutations across 21 cancers to identify driver genes and their associations with metabolism, immunity, and hypoxia.

Timing gone awry: distinct tumour suppressive and oncogenic roles of the circadian clock and crosstalk with hypoxia signalling in diverse malignancies

This study identifies circadian clock genes with tumour-suppressive and oncogenic roles across 21 cancer types, showing their prognostic significance and interactions with hypoxia signalling.

Aberrations in Notch-Hedgehog signalling reveal cancer stem cells harbouring conserved oncogenic properties associated with hypoxia and immunoevasion

The paper identifies a Notch-Hedgehog gene signature associated with cancer stem cells, showing its predictive value across five cancers and linking it to hypoxia and immunoevasion.

Pan-cancer genomic amplifications underlie a Wnt hyperactivation phenotype associated with stem cell-like features leading to poor prognosis

The paper identifies a core Wnt gene signature linked to genomic amplifications and poor prognosis across six cancer types.

Transcriptional landscape of DNA repair genes underpins a pan-cancer prognostic signature associated with cell cycle dysregulation and tumor hypoxia

The paper identifies a 10-gene DNA repair signature associated with poor prognosis in multiple cancers, linked to cell cycle dysregulation and tumor hypoxia.

Dual prognostic role for 2-oxoglutarate oxygenases in ten diverse cancer types: Implications for cell cycle regulation and cell adhesion maintenance

The paper identifies two prognostic signatures of 2-oxoglutarate oxygenases in 10 cancers, showing associations with survival outcomes and potential roles in cell cycle regulation and cell adhesion.

A novel signature derived from immunoregulatory and hypoxia genes predicts prognosis in liver and five other cancers

The paper develops a 45-gene and an 8-gene signature combining hypoxia and immunoregulatory genes to predict prognosis across six cancer types, showing improved performance over existing staging parameters.

The innate immune systems of malacostracan crustaceans exhibit both conserved and evolutionarily distinct components

This study identifies conserved and divergent components of the innate immune system in malacostracan crustaceans using comparative genomics.

Analyses of the core eukaryotic protein subunit of telomerase support extensive adaptation to different evolutionary and life histories in the Metazoa

This study analyzes TERT sequence and regulatory evolution across Metazoa, revealing extensive adaptation to diverse life histories and evolutionary pressures.