Mitochondrial electron transport chain, ceramide and Coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle
A. D. Vegas, S. Madsen, K. C. Cooke, L. Carroll, J. X. Y. Khor, N. Turner, X. Y. Lim, M. A. Astore, J. Morris, A. S. Don, A. Garfield, S. Zarini, K. A. Zemski Berry, A. P. Ryan, B. C. Bergman, , J. G. Burchfield
The paper links mitochondrial ceramide, CoQ, and the respiratory chain in a pathway driving insulin resistance in skeletal muscle, showing protective effects of reducing ceramide or supplementing CoQ.
bioRxiv · Mar 10, 2023 · PreprintCell Biology