N. Turner

Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction

This study shows that reducing CERS1 in skeletal muscle worsens age-related muscle dysfunction in mice and humans, linking it to inflammation and fibrosis.

Mitochondrial electron transport chain, ceramide and Coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle

The paper links mitochondrial ceramide, CoQ, and the respiratory chain in a pathway driving insulin resistance in skeletal muscle, showing protective effects of reducing ceramide or supplementing CoQ.

Insulin sensitivity is preserved in mice made obese by feeding a high starch diet

This study shows that mice fed a high starch diet become obese but remain insulin sensitive, unlike those on a high fat diet, with differences in ceramide levels and lipogenesis contributing to this effect.

FACS-assisted single-cell lipidome analysis of phosphatidylcholines and sphingomyelins

This paper develops a high-throughput method for single-cell lipidomics that quantifies phosphatidylcholines and sphingomyelins using FACS, nanoESI, and shotgun lipidomics, enabling lineage distinction and subtle lipidome differences detection.

Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease

This study shows that acetyl-CoA metabolism in fatty liver disease leads to histone hyperacetylation, DNA damage, and increased mutation risk, contributing to hepatocellular carcinoma.

Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growth in vitro and in vivo

This study shows that inhibiting GMPS reduces glutamine metabolism and prostate cancer growth in vitro and in vivo.

The evolutionary origins and diversity of the neuromuscular system of paired appendages in batoids

This study investigates the developmental and evolutionary origins of neuromuscular systems in batoid fish, finding that paired fin muscles evolved from redeployed genetic programs involved in dorsal fin development.

Fibroblast activation protein enzyme deficiency prevents liver steatosis, insulin resistance and glucose intolerance and increases fibroblast growth factor-21 in diet induced obese mice

This study shows that FAP deficiency in diet-induced obese mice reduces liver steatosis, insulin resistance, and glucose intolerance while increasing FGF-21 levels.