Small-molecule P2RX7 activator sensitizes tumor to immunotherapy and vaccinates mouse against tumor re-challenge
L. Douguet, S. Janho dit hreich, J. Benzaquen, l. seguin, T. Juhel, X. Dezitter, C. Duranton, B. Ryffel, J. Kanellopoulos, C. Delarasse, N. Renault, C. Furman, G. Homerin, C. Feral, J. Cherfils-Vicini, , V. Vouret-Craviari
The paper develops a P2RX7 activator that enhances immunotherapy efficacy and provides long-term tumor protection in mice.
bioRxiv · Nov 19, 2020 · PreprintCancer Biology