Author

B. Ryffel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:development & morphogenesis· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Sanz· 2 shared C. Wang· 2 shared G. Mbalaviele· 2 shared M. D. Cordero· 2 shared A. Gallardo-Orihuela· 1 shared A. Ghinet· 1 shared A. Janin· 1 shared B. Castejon-Vega· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersImmunology

A. Sanz

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

NLRP1 inflammasome modulates senescence and senescence-associated secretory phenotype

I. Muela-Zarzuela, J. M. Suarez-Rivero, A. Gallardo-Orihuela, C. Wang, K. Izawa, M. de Gregorio-Procopio, I. Couillin, B. Ryffel, J. Kitaura, A. Sanz, T. von Zglinicki, G. Mbalaviele, M. D. Cordero

This study shows that NLRP1 inflammasome promotes senescence and SASP through GSDMD-dependent regulation of p16, p21, p53, and SASP expression.

bioRxiv · Feb 6, 2023 · PreprintImmunology

Small-molecule P2RX7 activator sensitizes tumor to immunotherapy and vaccinates mouse against tumor re-challenge

L. Douguet, S. Janho dit hreich, J. Benzaquen, l. seguin, T. Juhel, X. Dezitter, C. Duranton, B. Ryffel, J. Kanellopoulos, C. Delarasse, N. Renault, C. Furman, G. Homerin, C. Feral, J. Cherfils-Vicini, , V. Vouret-Craviari

The paper develops a P2RX7 activator that enhances immunotherapy efficacy and provides long-term tumor protection in mice.

bioRxiv · Nov 19, 2020 · PreprintCancer Biology

Inhibition of the NLRP3 inflammasome prevents ovarian aging

J. M. Navarro-Pando, E. Alcocer-Gomez, B. Castejon-Vega, J. Muntane, C. Wang, H. M. Hoffman, A. Sanz, G. Mbalaviele, B. Ryffel, M. D. Cordero

This study shows that inhibiting the NLRP3 inflammasome improves ovarian function and fertility in aging mice by enhancing AMH, autophagy, and reducing FSH and estradiol levels.

bioRxiv · Apr 26, 2020Immunology

Muc5b-deficient mice develop early histological lung abnormalities

H. Valque, V. Gouyer, C. Duez, C. Leboeuf, P. Marquillies, M. Lebert, S. Plet, B. Ryffel, A. Janin, F. Gottrand, J.-L. Desseyn

This study shows that Muc5b-deficient mice develop early lung abnormalities, including structural and functional impairments, highlighting Muc5b's essential role in lung health.

bioRxiv · Jul 17, 2019Physiology