MDM2 stabilization of Notch intracellular domain upon DNA damage plays a major role in non-small cell lung carcinoma response to platinum chemotherapy
S. Bernardo, Q. D. Thomas, M. Mancini, A. Santos, S. F. Rasamizafy, A. M. Maacha, A. Giry, e. Bousquet-Mur, L. Papon, M. Goussard, C. Fremin, A. Pasquier, M. Rodriguez, C. Travert, J. L. Pujol, , A. Maraver
This study identifies MDM2 stabilization of NICD in response to platinum chemotherapy in NSCLC, showing that targeting MDM2 and NICD improves survival and reduces tumor growth.
bioRxiv · Apr 29, 2024 · PreprintCancer Biology