Significance of Oct-4 transcription factor as a pivotal therapeutic target for CD44+/24- mammary tumour initiating cells; aiming at the root of the recurrence
U. Sen, S. Shanavas, A. Gowda, M. Nihad, H. K. Rachamalla, R. Banerjee, S. Shenoy P, B. Bose
This study identifies Oct-4 as a survival factor in breast cancer stem cells (bCSCs) and shows its knockdown induces apoptosis, morphology changes, and reduced mammosphere formation.
bioRxiv · May 21, 2021 · PreprintCancer Biology