Nirmatrelvir, an orally active Mpro inhibitor, is a potent inhibitor of SARS-CoV-2 Variants of Concern
D. K. Rai, I. Yurgelonis, P. McMonagle, H. A. Rothan, L. Hao, A. Gribenko, E. Titova, B. Kreiswirth, K. M. White, Y. Zhu, A. S. Anderson, R. D. Cardin
This paper evaluates the antiviral activity of Nirmatrelvir against multiple SARS-CoV-2 variants using qRT-PCR in VeroE6 cells, showing potent inhibition across all tested variants.
bioRxiv · Jan 17, 2022Microbiology