L. Hao

Contaminant Spot Check and Removal Assay (ContamSPOT) for Mass Spectrometry Analysis

The paper introduces ContamSPOT, a method to detect and remove trace contaminants in mass spectrometry samples using TLC plates, improving data quality and instrument longevity.

Orphan nuclear receptor NR2E3 and its small-molecule agonist induce cancer cell apoptosis through regulating p53, IFNα and MYC pathways

This study shows NR2E3 activates p53 and induces apoptosis in cancer cells, with its agonist 11a synergizing with Romidepsin to suppress cervical cancer through multiple molecular mechanisms.

SntB triggers the antioxidant pathways to regulate development and aflatoxin biosynthesis in Aspergillus flavus

This study identifies SntB as a regulator of growth, development, and aflatoxin biosynthesis in Aspergillus flavus by modulating antioxidant pathways and gene expression.

E. coli RecBCD Nuclease Domain Regulates Helicase Activity but not Single Stranded DNA Translocase Activity

This study shows that the nuclease domain of E. coli RecBCD affects dsDNA unwinding rates but not ssDNA translocation, suggesting the nuclease domain influences base pair melting rather than translocation.

Inhalable point-of-care urinary diagnostic platform

This paper introduces a point-of-care diagnostic platform for lung cancer using inhalable nanosensors that detect tumor-associated proteases through urine analysis.

Efficacy of Parainfluenza Virus 5 (PIV5)-vectored Intranasal COVID-19 Vaccine as a Single Dose Vaccine and as a Booster against SARS-CoV-2 Variants

This paper evaluates the immunogenicity and efficacy of PIV5-vectored COVID-19 vaccines against SARS-CoV-2 variants in hamsters, showing they induce strong neutralizing antibodies and provide protection as single doses or boosters.

Replicating RNA platform enables rapid response to the SARS-CoV-2 Omicron variant and elicits enhanced protection in naïve hamsters compared to ancestral vaccine

Nirmatrelvir, an orally active Mpro inhibitor, is a potent inhibitor of SARS-CoV-2 Variants of Concern

This paper evaluates the antiviral activity of Nirmatrelvir against multiple SARS-CoV-2 variants using qRT-PCR in VeroE6 cells, showing potent inhibition across all tested variants.

Dihydroartemisinin broke immune evasion through YAP1/JAK1/STAT1, 3 pathways to enhance anti-PD-1 therapy in hepatocellular carcinoma

This study shows dihydroartemisinin (DHA) enhances anti-PD-1 therapy in hepatocellular carcinoma by inhibiting YAP1 and disrupting immune evasion through PD-L1, JAK1/STAT1, and JAK3 pathways.

Neuropilin-1 Mediates SARS-CoV-2 Infection in Bone Marrow-derived Macrophages

This study shows SARS-CoV-2 infects bone marrow-derived macrophages via neuropilin-1, not ACE2, and affects osteoclast function.

Characterizing the growing microorganisms at species level in 46 anaerobic digesters at Danish wastewater treatment plants: A six-year survey on microbiome structure and key drivers

This study characterizes the microbial communities in 46 anaerobic digesters over six years, identifying key drivers shaping microbiome structure and highlighting the role of immigration in bacterial diversity.

The female urinary microbiota in relation to the reproductive tract microbiota

The study analyzes the urinary microbiota of 147 Chinese women, revealing non-sterile urine with distinct bacterial communities and showing similarity to cervical and uterine microbiota rather than vaginal microbiota.

CRISPR-Cas-amplified urine biomarkers for multiplexed and portable cancer diagnostics

This paper develops CRISPR-Cas-amplified urine biomarkers for noninvasive cancer detection and monitoring in murine models.

Personalized vagino-cervical microbiome dynamics after oral probiotics

The study tracks vagino-cervical microbiome changes in 60 women over a year after oral probiotics, finding no colonization but stability in Lactobacillus-dominated communities and potential benefits for some individuals.

Life history recorded in the vagino-cervical microbiome

This study analyzes the vagino-cervical microbiome of 516 women using metagenomic shotgun sequencing to explore how pregnancy, delivery, and contraception influence microbiome composition.

Low-dose cadmium potentiates lung inflammatory response to 2009 pandemic H1N1 influenza virus in mice

This study shows that low-dose cadmium exposure in mice increases lung inflammation and genetic responses to H1N1 influenza virus infection.