Using a fragment-based approach to identify novel chemical scaffolds targeting the dihydrofolate reductase (DHFR) from Mycobacterium tuberculosis
J. A. Ribeiro, A. Hammer, G. A. L. Zuniga, S. M. Chavez-Pacheco, P. Tyrakis, G. S. de Oliveira, T. Kirkman, J. El Bakali, S. A. Rocco, M. L. Sforca, R. Parise-Filho, A. G. Coyne, T. L. Blundell, C. Abell, M. V. B. Dias
This study uses fragment-based drug discovery to identify novel chemical scaffolds targeting Mycobacterium tuberculosis DHFR, revealing a new binding mode and low micromolar affinity compounds.
bioRxiv · Mar 30, 2020Biochemistry