Author

J. El Bakali

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:protein structure prediction· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

A. G. Coyne· 2 shared C. Abell· 2 shared M. V. B. Dias· 2 shared T. L. Blundell· 2 shared A. Hammer· 1 shared C. Spry· 1 shared G. A. L. Zuniga· 1 shared G. S. de Oliveira· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

A. G. Coyne

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2 papers

Recent·Most cited

BiochemistrybioRxivSep 4, 2020

Chemical validation of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase using fragment linking and CRISPR interference

J. El Bakali, M. Blaszczyk, J. C. Evans…·C. Spry

This study identifies inhibitors of MtbPPAT, a key enzyme in CoA biosynthesis, using fragment linking and CRISPR interference to validate it as a potential anti-TB drug target.

DOI 10.1002/anie.202300221

bacteria (other)experimental assay

𝕏 PostBluesky

BiochemistrybioRxivMar 30, 2020

Using a fragment-based approach to identify novel chemical scaffolds targeting the dihydrofolate reductase (DHFR) from Mycobacterium tuberculosis

J. A. Ribeiro, A. Hammer, G. A. L. Zuniga…·M. V. B. Dias

This study uses fragment-based drug discovery to identify novel chemical scaffolds targeting Mycobacterium tuberculosis DHFR, revealing a new binding mode and low micromolar affinity compounds.

DOI 10.1021/acsinfecdis.0c00263

bacteria (other)experimental assay

𝕏 PostBluesky