Author

A. Hatoum-Aslan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:bacteria (other)· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:gene regulatory network inference· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

L. Chou-Zheng· 3 shared B. Aslan· 2 shared A. Thomas· 1 shared J. L. Kizziah· 1 shared K. Cater· 1 shared M. Hossain· 1 shared N. C. Hawkins· 1 shared O. Howell· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMicrobiology

L. Chou-Zheng

Mutual co-authors in cluster

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5 papers

Recent·Most cited

Tandem mobilization of anti-phage defenses alongside SCCmec cassettes

M. Hossain, B. Aslan, A. Hatoum-Aslan

The paper shows that SCCmec cassettes in staphylococci spread anti-phage defenses and antibiotic resistance through recombinases, highlighting their role in horizontal gene transfer.

Nature Communications · Oct 12, 2024Peer-reviewedMicrobiology

Structure and host specificity of Staphylococcus epidermidis bacteriophage Andhra

N. C. Hawkins, J. L. Kizziah, A. Hatoum-Aslan, T. Dokland

This study determines the structure of Staphylococcus epidermidis bacteriophage Andhra using cryo-EM, revealing key features for host recognition and therapeutic development.

bioRxiv · Jul 21, 2022Microbiology

Critical roles for 'housekeeping' nucleases in Type III CRISPR-Cas immunity

L. Chou-Zheng, A. Hatoum-Aslan

This study identifies RNase R as a third nuclease essential for Type III CRISPR-Cas immunity, working with PNPase to mature crRNAs and eliminate invading nucleic acids.

bioRxiv · Jul 18, 2022Microbiology

A unique mode of nucleic acid immunity performed by a single multifunctional enzyme

S. M. N. Bari, L. Chou-Zheng, O. Howell, K. Cater, V. S. Dandu, A. Thomas, B. Aslan, A. Hatoum-Aslan

This study identifies a single multifunctional enzyme, Nhi, that provides robust nucleic acid immunity against phages by acting as both sensor and effector.

bioRxiv · Aug 30, 2021Microbiology

A Type III-A CRISPR-Cas system employs degradosome nucleases to ensure robust immunity

L. Chou-Zheng, A. Hatoum-Aslan

This study shows that a Type III-A CRISPR-Cas system in Staphylococcus epidermidis uses PNPase and RNase J2 degradosome nucleases for crRNA maturation and phage defense.

bioRxiv · Feb 8, 2019Microbiology