A GGDEF domain serves as a spatial on-switch for a phosphodiesterase by direct interaction with a polar landmark protein
T. Rick, V. Kreiling, A. Hoing, S. Fiedler, T. Glatter, W. Steinchen, G. Hochberg, H. Bahre, R. Seifert, G. Bange, S. K. Knauer, P. L. Graumann, K. M. Thormann
The paper shows how the GGDEF domain of PdeB acts as a spatial on-switch by interacting with HubP to restrict phosphodiesterase activity to the flagellated cell pole, influencing surface interaction and environmental spreading.
bioRxiv · Aug 12, 2021Microbiology