A KDM4A-PAF1-mediated epigenomic network is essential for acute myeloid leukemia cell self-renewal and survival
M. E. Massett, L. Monaghan, S. D. Patterson, N. Mannion, R. P. Bunschoten, A. Hoose, S. Marmiroli, R. M. Liskamp, H. G. Jorgensen, D. Vetrie, A. M. Michie, X. Huang
This study identifies KDM4A's role in AML by showing its regulation of an epigenomic network critical for cell survival and self-renewal, and highlights a gene signature for risk stratification.
bioRxiv · Oct 30, 2020Cancer Biology