Sirt5 deficiency causes post-translational protein malonylation and dysregulated cellular metabolism in chondrocytes under obesity conditions
S. Zhu, A. Batushansky, A. Jopkiewicz, D. Makosa, K. M. Humphries, H. Van Remmen, T. M. Griffin
This study shows that Sirt5 deficiency increases protein malonylation and disrupts metabolism in chondrocytes under obesity conditions, linking it to osteoarthritis progression.
bioRxiv · Nov 30, 2020Cell Biology