Stimulatory effect of monoacylglycerol lipase inhibitor MJN110 on locomotion and step kinematics demonstrated by high-precision 3D motion capture in mice
B. M. Ignatowska-Jankowska, A. Gurkan Ozer, A. Kuck, M. J. Niphakis, D. Ogasawara, B. F. Cravatt, M. Y. Uusisaari
This study shows that inhibiting monoacylglycerol lipase (MJN110) enhances locomotion and step kinematics in mice, while inhibiting fatty acid amide hydrolase (PF3845) suppresses it, revealing distinct effects of endocannabinoid pathway manipulations on motor behavior.
bioRxiv · Jun 25, 2023 · PreprintAnimal Behavior & Cognition