Extracellular matrix sulfation in the tumor microenvironment stimulates cancer stemness and invasiveness
A. Kusoglu, D. Ornek, A. Dansik, C. Uzun, S. N. Ozkan, S. Sarica, K. Yangin, S. Ozdinc, D. Turan Sorhun, N. Solcan, E. C. Doganalp, O. Arlov, K. Cunningham, I. C. Karaoglu, S. Kizilel, , E. Ozturk
The paper shows that increased sulfation in tumor ECM promotes cancer stemness and invasiveness through FAK-PI3K-mTOR signaling and RTK activation.
bioRxiv · Oct 17, 2023Bioengineering