OPTN translocates to an ATG9A-positive compartment to regulate innate immune signalling and cytokine secretion
T. O'Loughlin, A. J. Kruppa, A. L. Ribeiro, J. R. Edgar, A. Ghannam, A. M. Smith, F. Buss
The paper shows OPTN regulates innate immune signaling by forming a perinuclear compartment with ATG9A, and disease mutations disrupt this process, affecting cytokine secretion.
bioRxiv · Aug 22, 2019 · PreprintCell Biology