Cell BiologybioRxiv
A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease
DOI 10.1038/s44318-024-00328-6
Author
J. R. Edgar
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2018-2023 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 23 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship6 papers
Recent·Most cited
- MicrobiologybioRxiv
The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity
H. Stewart, Y. Lu, S. O'Keefe…·A. E. Firth
This study identifies ORF3c as a SARS-CoV-2 protein that localizes to mitochondria and inhibits IFN-β production without affecting NF-κB or JAK-STAT signaling.
DOI 10.1016/j.isci.2023.108080 - MicrobiologybioRxivPreprint
Ultrastructural insight into SARS-CoV-2 attachment, entry and budding in human airway epithelium
A. L. Pinto, R. K. Rai, J. C. Brown…·T. Burgoyne
This study uses electron microscopy to examine SARS-CoV-2 infection in human airway epithelium, showing viral entry through the plasma membrane and budding from intracellular compartments.
- Cell BiologybioRxiv
Tetherin antagonism by SARS-CoV-2 enhances virus release: multiple mechanisms including ORF3a-mediated defective retrograde traffic
H. Stewart, R. Palmulli, K. H. Johansen…·J. R. Edgar
This study shows SARS-CoV-2 evades tetherin restriction by multiple mechanisms, including ORF3a disrupting tetherin localization and Spike protein reducing tetherin levels, enhancing viral release.
DOI 10.15252/embr.202357224 - Cell BiologybioRxivPreprint
OPTN translocates to an ATG9A-positive compartment to regulate innate immune signalling and cytokine secretion
T. O'Loughlin, A. J. Kruppa, A. L. Ribeiro…·F. Buss
The paper shows OPTN regulates innate immune signaling by forming a perinuclear compartment with ATG9A, and disease mutations disrupt this process, affecting cytokine secretion.
DOI 10.1101/744672 - Cell BiologybioRxiv
AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A
A. K. Davies, D. N. Itzhak, J. R. Edgar…·G. H. H. Borner
The paper identifies AP-4's role in ATG9A trafficking via RUSC2-mediated vesicle transport, linking AP-4 deficiency to autophagy dysregulation in multiple cell types.
DOI 10.1038/s41467-018-06172-7