Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues
E. T. Tjhin, C. Spry, A. L. Sewell, A. Hoegl, L. Barnard, A. E. Sexton, V. M. Howieson, A. G. Maier, D. J. Creek, E. Strauss, R. Marquez, K. Auclair, K. J. Saliba
The paper identifies mutations in Plasmodium falciparum pantothenate kinase genes that confer resistance to pantothenate analogues and reveal different mechanisms of action for these compounds.
bioRxiv · Jul 24, 2017Pharmacology & Toxicology