K. Auclair

Efficient mechano-enzymatic hydrolysis of polylactic acid under moist-solid conditions.

This study demonstrates efficient mechano-enzymatic hydrolysis of polylactic acid to lactic acid under moist-solid conditions using Humicola insolens cutinase, enabling closed-loop recycling with minimal solvent waste.

Solid-state enzymatic hydrolysis of mixed PET-cotton textiles

This paper develops a method to enzymatically hydrolyze mixed PET-cotton textiles without prior melt-amorphization, achieving high yields of TPA and glucose.

Structural dynamics of cytochrome P450 3A4 in the presence of substrates and cytochrome P450 reductase

This study uses HDX-MS to show that CYP3A4 rigidifies upon binding substrates or CPR, affecting conformational dynamics and suggesting allostery mechanisms.

Exploring heteroaromatic rings as a replacement for the labile amide of antiplasmodial pantothenamides

This study replaces the amide group in pantothenamides with heteroaromatic rings to improve antiplasmodial activity against Plasmodium species.

The antimicrobial activity of the macrophage metabolite itaconate is synergistic with acidity.

This study shows itaconate's antimicrobial activity synergizes with acidity, suggesting it may function in acidic environments like phagolysosomes and highlights potential therapeutic strategies.

Small molecule resensitizes Salmonella to itaconate and decreases bacterial proliferation in macrophages

Clean Enzymatic depolymerization of highly crystalline polyethylene terephthalate in moist-solid reaction mixtures

This study demonstrates that enzymes can efficiently depolymerize high crystallinity PET in moist-solid mixtures, achieving higher yields and selectivity than previous methods.

Combining small-molecule bioconjugation and hydrogen-deuterium exchange mass spectrometry (HDX-MS) to expose allostery: the case of human cytochrome P450 3A4

The paper combines bioconjugation and HDX-MS to study allostery in CYP3A4, identifying key regions involved in activation.

Rapid mechanoenzymatic saccharification of lignocellulosic biomass without bulk water or chemical pre-treatment

This paper demonstrates a solvent-free enzymatic method for lignocellulosic biomass saccharification with high yield and low protein loading, producing concentrated monosaccharides without chemical pre-treatment.

Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues

The paper identifies mutations in Plasmodium falciparum pantothenate kinase genes that confer resistance to pantothenate analogues and reveal different mechanisms of action for these compounds.