Intramolecular quality control: HIV-1 Envelope gp160 signal-peptide cleavage as a functional folding checkpoint
N. D. McCaul, M. Quandte, I. Bontjer, G. van Zadelhoff, A. Land, R. W. Sanders, I. Braakman
The paper shows that the HIV-1 gp120 signal peptide remains attached during folding, enhancing conformational plasticity and ensuring only properly folded gp120 is released.
bioRxiv · Jul 8, 2020Biochemistry