Author

I. Bontjer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 5 Assay:proteomics· 4 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:virus· 2 Research Focus:cell type annotation· 1 Assay:flow cytometry· 1

Frequent Co-Authors

R. W. Sanders· 6 shared A. B. Ward· 5 shared K. Sliepen· 5 shared G. Kerster· 4 shared J. A. Burger· 4 shared M. Brinkkemper· 4 shared M. Claireaux· 4 shared M. Poniman· 4 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

6 shared papersImmunology

R. W. Sanders

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Bispecific antibodies combine breadth, potency, and avidity of parental antibodies to neutralize sarbecoviruses

L. Radic, K. Sliepen, V. Yin, M. Brinkkemper, J. Capella-Pujol, A. I. Schriek, J. L. Torres, S. Bangaru, J. A. Burger, M. Poniman, I. Bontjer, J. H. Bouhuijs, D. Gideonse, D. Eggink, A. B. Ward, , J. Schinkel

This study shows bispecific antibodies combine the neutralizing breadth and potency of parental antibodies to neutralize SARS-CoV and SARS-CoV-2 variants, including Omicron.

bioRxiv · Nov 11, 2022Immunology

Broad SARS-CoV-2 Neutralization by Monoclonal and Bispecific Antibodies Derived from a Gamma-infected Individual

D. Guerra, T. Beaumont, L. Radic, G. Kerster, K. van der Straten, M. Yuan, J. L. Torres, W.-H. Lee, H. Liu, M. Poniman, I. Bontjer, J. A. Burger, M. Claireaux, T. G. Caniels, J. L. Snitselaar, , M. J. van Gils

This study identifies broadly neutralizing monoclonal and bispecific antibodies from a Gamma variant-infected individual that effectively neutralize multiple SARS-CoV-2 variants.

bioRxiv · Oct 14, 2022Immunology

CD4 binding-site antibodies induced by a subtype B HIV-1 envelope trimer

A. Schorcht, T. L. G. M. van den Kerkhof, J. Torres, E. Schermer, C. LaBranche, I. Bontjer, M. Brinkkemper, N. Gulzar, A. X. Han, J. Burger, G. Ozorowski, J. Scott, H. Schuitemaker, D. Montefiori, M. van Gils, , R. W. Sanders

This study shows that immunization with native-like HIV-1 subtype B Env trimers can induce CD4bs-directed broadly neutralizing antibodies in rabbits.

bioRxiv · Mar 23, 2022 · PreprintImmunology

A public antibody class recognizes a novel S2 epitope exposed on open conformations of SARS-CoV-2 spike

M. Claireaux, T. G. Caniels, M. de Gast, J. Han, D. Guerra, G. Kerster, B. D. van Schaik, A. Jongejan, A. I. Schriek, M. Grobben, P. J. Brouwer, K. van der Straten, Y. Aldon, J. Capella-Pujol, J. L. Snitselaar, , M. J. van Gils

The paper identifies a novel S2 epitope recognized by a public antibody class in SARS-CoV-2-reactive B cells, which becomes exposed on vaccine-optimized spike proteins.

bioRxiv · Dec 1, 2021Immunology

Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection

P. J. M. Brouwer, M. Brinkkemper, P. Maisonnasse, N. Dereuddre-Bosquet, M. Grobben, M. Claireaux, M. de Gast, R. Marlin, V. Chesnais, S. Diry, J. D. Allen, Y. Watanabe, J. M. Griezen, G. Kerster, H. L. Turner, , de Bree

This paper develops a two-component spike nanoparticle vaccine that protects macaques from SARS-CoV-2 infection by inducing strong neutralizing antibodies and reducing viral replication.

bioRxiv · Nov 7, 2020Immunology

Intramolecular quality control: HIV-1 Envelope gp160 signal-peptide cleavage as a functional folding checkpoint

N. D. McCaul, M. Quandte, I. Bontjer, G. van Zadelhoff, A. Land, R. W. Sanders, I. Braakman

The paper shows that the HIV-1 gp120 signal peptide remains attached during folding, enhancing conformational plasticity and ensuring only properly folded gp120 is released.

bioRxiv · Jul 8, 2020Biochemistry

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

P. Brouwer, T. Caniels, K. van Straten, J. Snitselaar, Y. Aldon, S. Bangaru, J. Torres, N. Okba, M. Claireaux, G. Kerster, A. Bentlage, M. van Haaren, D. Guerra, J. Burger, E. Schermer, , M. van Gils

This study isolates potent neutralizing antibodies from COVID-19 patients that target multiple sites on the SARS-CoV-2 spike protein, offering insights for vaccine design and therapeutic development.

bioRxiv · May 12, 2020Microbiology

Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens

A. Antanasijevic, G. Ueda, J. Copps, P. J. Brouwer, D. Huang, J. D. Allen, C. A. Cottrell, A. Yasmeen, L. M. Sewall, I. Bontjer, T. J. Ketas, H. L. Turner, Z. T. Berndsen, P. J. Klasse, M. Crispin, , A. B. Ward

The paper evaluates de novo-designed two-component nanoparticles for presenting HIV Env trimers, showing improved antibody responses through multivalent display.

bioRxiv · Jan 31, 2020Immunology