Deep multi-omic profiling reveals extensive mitochondrial remodeling driven by glycemia in early diabetic kidney disease
C. Granata, V. Thallas-Bonke, N. j. Caruana, K. Huynh, C. X. Qin, A. Laskowski, M. Snelson, J. Anthonisz, E. Jap, G. Ramm, M. E. Cooper, P. Meikle, D. A. Stroud, R. H. Ritchie, M. T. Coughlan
This study shows that blood glucose levels directly affect mitochondrial function and metabolism in early diabetic kidney disease, with changes in proteome, metabolome, and lipidome.
bioRxiv · Oct 26, 2023 · PreprintCell Biology