C. Granata

Deep multi-omic profiling reveals extensive mitochondrial remodeling driven by glycemia in early diabetic kidney disease

This study shows that blood glucose levels directly affect mitochondrial function and metabolism in early diabetic kidney disease, with changes in proteome, metabolome, and lipidome.

Fibre-specific mitochondrial protein abundance is linked to resting and post-training mitochondrial content in human muscle.

The paper examines fibre-specific mitochondrial protein abundance in human muscle before and after training, finding that most differences are linked to mitochondrial content rather than fibre-type-specific remodelling.

Methodological considerations when assessing mitochondrial respiration and biomarkers for mitochondrial content in human skeletal muscle

This paper evaluates the reliability and reproducibility of methods for measuring mitochondrial respiration and citrate synthase activity in human skeletal muscle, identifying technical and biological variability factors.

Training-induced bioenergetic improvement in human skeletal muscle is associated with non-stoichiometric changes in the mitochondrial proteome without reorganization of respiratory chain content

The paper investigates training-induced mitochondrial adaptations in human skeletal muscle, finding non-stoichiometric changes in the proteome and challenging previous assumptions about bioenergetic improvements.

Forty high-intensity interval training sessions blunt exercise-induced changes in the nuclear protein content of PGC-1α and p53 in human skeletal muscle

This study shows that 40 sessions of high-intensity interval training reduce exercise-induced increases in nuclear PGC-1α, p53, and related markers of mitochondrial biogenesis in human skeletal muscle.