A dynamic control of human telomerase holoenzyme
M. Sayed, A. Cheng, G. Yadav, A. Ludlow, J. W. Shay, W. E. Wright, Q.-X. Jiang
The paper demonstrates that human telomerase holoenzymes have fast- and slow-acting catalytic sites that become inactive after two rounds of catalysis, and can be reactivated by intracellular factors.
bioRxiv · Jan 21, 2019 · PreprintCell Biology