Macrophages inhibit Coxiella burnetii by the ACOD1-itaconate pathway for containment of Q fever
L. Kohl, N. A. A. Siddique, B. Bodendorfer, R. Berger, A. Preikschat, C. Daniel, M. Oelke, M. Mauermeir, K.-T. Yang, I. Hayek, M. Szperlinski, J. Schulze-Luehrmann, U. Schleicher, A. Bozec, G. Kroenke, , R. Lang
This study identifies the ACOD1-itaconate pathway in macrophages as critical for restricting Coxiella burnetii replication and proposes it as a therapeutic target for Q fever.
bioRxiv · May 10, 2022Immunology