Oncogenic Mutations in Histologically Normal Endometrium: The New Normal?
V. Lac, T. M. Nazeran, B. Tessier-Cloutier, R. Aguirre-Hernandez, A. Albert, A. Lum, J. Khattra, T. Praetorius, M. Mason, D. Chiu, M. Köbel, P. J. Yong, B. C. Gilks, M. S. Anglesio, D. G. Huntsman
This study finds that over 50% of histologically normal endometrium samples contain somatic driver mutations, including KRAS, PIK3CA, FGFR2, and PTEN loss, with prevalence increasing with age.
bioRxiv · Feb 26, 2019Pathology