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Elevated precontractile calcium set point is sustained by limited PMCA1 export in dystrophic muscle

The paper shows that dystrophic muscle has an elevated precontractile calcium set point sustained by limited PMCA1 export in C. elegans and human myoblasts.

Systematic comparison of gliflozins identifies a selective anti-calcifying effect of canagliflozin beyond canonical SGLT2 inhibition

This study compares gliflozins and finds canagliflozin uniquely reduces vascular calcification through mechanisms beyond SGLT2 inhibition, affecting VSMC metabolism and calcification.

Midlife nonlinearities across scale in Biondi body amyloid formation in the human choroid plexus

The paper examines age-related accumulation of Biondi bodies in human choroid plexus epithelial cells, finding nonlinear increases in prevalence and load, and suggesting prion-like spread mechanisms.

Hypoxemia is an Independent Risk Factor for Perioperative Thrombosis at High Altitude: A Retrospective Study of 11,084 Patients

Failed allogeneic corneal lenticules show fibrosis and identity loss without dominant T cell rejection

The paper examines failed allogeneic corneal lenticules, finding fibrosis and loss of corneal identity without dominant T cell rejection, and explores treatment strategies.

Histopathological and virus-associated features of Boid Inclusion Body Disease in Boa constrictor

This study examines histopathological and viral protein expression features of Boid Inclusion Body Disease in boa constrictors, finding higher IB and NP scores in recent cases and no significant link between NP scores and inflammation.

Transmural Single-Nucleus Transcriptomics Nominates Candidate Disease Programs in Human Necrotizing Enterocolitis

The paper uses single-nucleus RNA sequencing to analyze intestinal tissues from NEC patients and controls, identifying disease-specific gene expression programs across multiple cell types.

Explainable Multimodal Prognostic Modeling Uncovers New Clinically Relevant Pathological Features in a Multi-Institutional Pancreatic Neuroendocrine Tumor Cohort

This paper develops a multimodal prognostic model for pancreatic neuroendocrine tumors using clinicopathologic data and histology images, finding that stromal features are as prognostic as tumor cells.

Short-term changes in a chicken comb vascular model mimicking port-wine stain after synchronous ultrasound parallel beam treatment: an exploratory study

This study examines the short-term effects of SUPERB ultrasound treatment on a chicken comb model, finding reduced vascular caliber and VEGF-A expression but no consistent collagen changes.

Role of the gut microbiota in the remodelling of the jejunal, colonic, hepatic and blood proteomes in a mouse model of Anorexia Nervosa

This study investigates proteome changes in multiple organs of mice with Anorexia Nervosa using a gut microbiota-depleted model, identifying microbiota-dependent and -independent protein alterations.

Light-sheet fluorescence microscopy of optically cleared human head-and-neck organs: three-dimensional tissue assessment and histological correlation

This study uses optical clearing and light-sheet fluorescence microscopy to visualize 3D microanatomy of human head-and-neck tissues and correlate it with conventional histology.

Comparison of Hydroponic and Substrate-Based Methods for Screening Pea Genotypes for Resistance to Fusarium oxysporum.

This study compares hydroponic and substrate-based methods for evaluating pea genotype resistance to Fusarium oxysporum, finding hydroponics more sensitive in distinguishing susceptible genotypes.

Pathology foundation-model embeddings reveal a morphological landscape of breast lesions beyond diagnostic categories

This paper uses morphology-based foundation-model embeddings to define a morphologic state space across breast lesion categories, revealing a pathobiological continuum associated with tumor development.

Loss of stromal VEGFR2 protects against ischemic acute kidney injury by preserving the renal microvasculature

This study shows that loss of stromal VEGFR2 protects against ischemic AKI by preserving the renal microvasculature through enhanced endothelial function and communication.

Pharmacological activation of mitophagy prevents calcific aortic valve disease by targeting dysregulated mitochondrial-to-nuclear communication

This study shows that activating mitophagy with TJ0113 prevents calcific aortic valve disease by restoring mitochondrial-to-nuclear communication disrupted in diseased valves.

Biomechanical stress in the retinal pigment epithelium surrounding laser scars in humans

The paper investigates how biomechanical stress in the retinal pigment epithelium (RPE) contributes to the enlargement of laser scars over time using imaging and histological analysis.

NAD boosting by CD38 inhibition drives reversal of a pathological vicious cycle of intracrine activity and inflammation in eyelid meibomian gland involution

This study shows that inhibiting CD38 boosts NAD levels, reversing a harmful cycle of inflammation and reduced intracrine activity in aged meibomian glands.

Rev-erb-alpha inhibits vascular calcification by repressing osteogenic reprogramming in atherosclerosis

This study identifies Rev-erb-alpha as a repressor of vascular calcification by inhibiting osteogenic reprogramming of vascular smooth muscle cells in atherosclerosis.

Digital pathological classification of peripheral neuroblastic tumors across multi-continent cohorts

The paper develops NB-PathAssist, a computational framework for automated classification of peripheral neuroblastic tumors using whole-slide histology images, achieving high accuracy in prognostic grouping.

AVPR2 antagonism with tolvaptan alters medullary cell responses and attenuates kidney injury

This study shows that Tolvaptan reduces medullary cell stress and inflammation in kidney injury models.