Functional differences drive the selection of NRAS mutants in melanoma
B. M. Murphy, T. J. Weiss, A. M. Holderbaum, A. Dhakal, M. Fort, M. S. Bodnar, M. Chen, C. J. Burd, V. COPPOLA, C. E. Burd
This study shows that specific NRAS mutants drive melanoma formation in mice, with Q61R and Q61K being the most effective, while others like G12D or Q61Q are not.
bioRxiv · Jan 15, 2021 · PreprintCancer Biology