Inhibition of Lactate Dehydrogenase A (LDH-A) by Diclofenac Sodium Induces Apoptosis in HeLa Cells by Activation of AMPK
This study shows that diclofenac inhibits LDH-A in HeLa cells, leading to ATP depletion, AMPK activation, and apoptosis via disruption of glycolytic metabolism.
bioRxiv · Oct 2, 2023 · PreprintCancer Biology