S. Gupta

High-yield production of recombinant human myelin oligodendrocyte glycoprotein in SHuffle bacteria without a refolding step

This paper describes a method to produce soluble recombinant human MOG in SHuffle bacteria without refolding, enabling B cell-dependent EAE studies.

Inseparable/IER3IP1 are essential for cytokinesis in Drosophila neuroblast and human cells

This study identifies Insep and IER3IP1 as essential for cytokinesis, showing their conserved role in Rab11 vesicle dynamics across Drosophila and human cells.

Electrochemical cofactor recycling of bacterial microcompartments

The paper identifies a new function of an enzyme in bacterial microcompartments, proposing NAD+ regeneration and a role for the shell in redox separation.

A structure-guided approach to predict MHC-I restriction of T cell receptors for public antigens

The paper predicts MHC-I restriction of T cell receptors for public antigens using structural analysis of TCR:pHLA complexes.

Developmental Control of Long-Distance mRNA Transport Involves m5C RNA Methylation and ALYREF Nuclear Export Factors

The paper investigates how m5C RNA methylation and ALY2/ALY4 nuclear export factors regulate mRNA transport during plant development, showing that this regulation changes with developmental stages.

Pattern of Alcohol tolerance and Adh gene Frequencies in Northern and Southern Populations of two Drosophila species from India.

This study examines alcohol tolerance and Adh gene frequencies in Drosophila populations across India, finding clinal variation linked to latitude and ecological niches.

Impedance-based assay for pan-cancer early and rapid detection of cell-free DNA

This paper introduces an impedance-based biosensor for rapid, label-free detection of cancer-associated cfDNA with high sensitivity and specificity across multiple cancer types.

Fur microbiome as a putative source of symbiotic bacteria in sucking lice

The paper investigates the origin of Neisseriaceae symbionts in rodent lice by analyzing the fur microbiome and proposes a hypothetical genome evolution scenario.

Structure and Functions of Gesture Sequences in Wild Bonnet Macaques (Macaca radiata)

This study examines gesture sequences in wild bonnet macaques, finding non-random combinations and specific functions, suggesting potential evolutionary links to human language.

Fitness Factor Genes Conserved within the Multi-species Core Genome of Gram-negative Enterobacterales Species Contribute to Bacteremia Pathogenesis

The paper identifies 18 conserved fitness genes in Enterobacterales species that contribute to bacteremia pathogenesis by testing mutants in a mouse model and finding attenuation in multiple organs.

Comparative Pore Structure and Dynamics for Bacterial Microcompartment Shell Protein Assemblies in Sheets or Shells

The paper compares pore structure and dynamics in bacterial microcompartment shell proteins under different geometries using molecular modeling and simulations.

Cellulose fermentation by the gut microbiota is likely not essential for the nutrition of millipedes

This study investigates whether gut microbiota fermentation is essential for millipede nutrition by disrupting microbiota in two species and analyzing metabolic and microbial responses.

The need for high-resolution gut microbiome characterization to design efficient strategies for sustainable aquaculture production

This study evaluates microbiota-directed fibers (MDFs) in Atlantic salmon diets, finding negligible effects on gut microbiome and host physiology, but identifying potential endogenous lactic acid bacteria for future MDF strategies.

Caenorhabditis elegans model for in vivo screening of human gut microbiota mediated colonization and colonization resistance against Clostridioides difficile

This study uses C. elegans to screen human gut microbiota for colonization and resistance against C. difficile, finding 46% colonization success and 50% in vivo inhibition of C. difficile.

Elucidating ATP's Role as Solubilizer of Biomolecular Aggregate

This study shows ATP prevents protein aggregation and dissolves pre-formed aggregates, suggesting it could be a therapeutic agent for protein-aggregation diseases.

Comparing multifunctional viral and eukaryotic proteins for generating scission necks in membranes

This study compares the membrane scission capabilities of viral and eukaryotic proteins using mechanical models and SAXS data to analyze how lipid composition and interfacial tension affect neck size.

The Salmon Microbial Genome Atlas enables novel insights into bacteria-host interactions via functional mapping

The paper presents the Salmon Microbial Genome Atlas, a collection of bacterial genomes from Atlantic salmon, and functionally characterizes key gut microbiota populations involved in nutrient processing and health.

Inhibition of Lactate Dehydrogenase A (LDH-A) by Diclofenac Sodium Induces Apoptosis in HeLa Cells by Activation of AMPK

This study shows that diclofenac inhibits LDH-A in HeLa cells, leading to ATP depletion, AMPK activation, and apoptosis via disruption of glycolytic metabolism.

DNA Tetrahedral Nanocages as a Promising Nanocarrier for Dopamine Delivery in Neurological Disorders

This study investigates DNA tetrahedral nanocages as a dopamine carrier for treating neurological disorders, showing their ability to deliver dopamine to cells and zebrafish embryos.

Nature-Inspired Peptide of MtDef4 C-terminus Tail Enables Protein Delivery in Mammalian Cells

This study evaluates a 16-residue peptide from Medicago truncatula defensin for its ability to penetrate mammalian cells and deliver cargo, showing efficient uptake and minimal cytotoxicity.

Chemokine receptor 5 signaling in PFC mediates stress susceptibility in female mice

This study shows that CCL5-CCR5 signaling in the prefrontal cortex of female mice contributes to stress susceptibility by altering microglia function and BBB integrity.

Hepatitis B virus x (HBx) protein increases cellular OCT3/4 and MYC and facilitates cellular reprogramming (of fibroblasts to iPSC)

This study shows HBx enhances reprogramming efficiency of fibroblasts to iPSC by increasing OCT3/4 and MYC levels, and can substitute MYC in the Yamanakas factor cocktail.

Identification of Sequence Determinants for the ABHD14 Enzymes

This study identifies key sequence determinants for ABHD14A and ABHD14B enzymes through bioinformatics and biochemical experiments, enabling better classification and evolutionary mapping.

Arsenophonus symbiosis with louse flies: multiple origins, coevolutionary dynamics, and metabolic significance

This study analyzes eleven Arsenophonus strains in louse flies, revealing multiple independent origins of symbiosis and differences in B vitamin synthesis capabilities.

Dopamine functionalized, red carbon quantum dots for in vivo bioimaging, cancer therapeutics, and neuronal differentiation

This paper develops dopamine-functionalized carbon quantum dots for bioimaging, cancer therapy, and neuronal differentiation using mango leaf extract.

Structural principles of peptide-centric Chimeric Antigen Receptor recognition guide therapeutic expansion

This paper determines the structure of a peptide-centric Chimeric Antigen Receptor (PC-CAR) complex and identifies structural principles for antigen recognition across multiple HLA allotypes.

Tackling emerging artemisinin resistance by modulating the defensive oxido-reductive mechanism of human malaria parasite by repurposing nitrofurantoin

This paper evaluates the anti-malarial potential of Nitrofurantoin against sensitive and resistant Plasmodium falciparum strains, finding synergistic effects with artemisinin and enhanced oxidative stress.

Identification of merozoite secreted repertoire and immuno-pharmacological inhibition of a novel host-parasite interaction to block malarial infection

This study identifies the secretory repertoire of Plasmodium merozoites and discovers a peptide that disrupts a key host-parasite interaction, blocking malarial infection.

Revealing dynamic temporal trajectories and underlying regulatory networks with Cflows

Cflows infers continuous cell state transitions and gene regulatory networks from static scRNA-seq data, revealing ESRRA as a key driver of tumor formation.

Growth-inhibiting effects of the unconventional plant APYRASE 7 of Arabidopsis thaliana influences the LRX1/FER/RALF growth regulatory module

This study identifies APY7 as a negative regulator of cell growth in Arabidopsis, showing it modulates RALF1's growth-inhibiting effect and affects cell wall architecture and extracellular pH.