Non-viral Intron Knockins Enable Simplified and Flexible Targeting of Endogenous Genes
T. L. Roth, J. Lu, A. McClellan, O. Takacsi-Nagy, A. L. Satpathy
This paper introduces non-viral intron targeting to improve genetic editing flexibility and simplify cell selection by integrating synthetic exons into endogenous introns.
bioRxiv · Mar 5, 2024 · PreprintBioengineering