J. Lu

GP130 Y814 SIGNALING IS REQUIRED FOR THE DYNAMIN-MEDIATED ENDOCYTOSIS, MAPK/P38 ACTIVATION AND PERSISTENCE OF CHRONIC SYSTEMIC INFLAMMATION INDUCED BY HIGH FAT DIET

This study shows that gp130-Y814 signaling is critical for dynamin-mediated endocytosis, MAPK/p38 activation, and chronic inflammation persistence in high-fat diet models.

FLASH proton reirradiation, with or without hypofractionation, mitigates chronic toxicity in the normal murine intestine, skin, and bone.

Innate immune system signaling and CD11b+CD11c+CD103+ cell migration to the brain underlie changes in mouse behavior after microbial colonization.

This study identifies innate immune signaling and CD11b+CD11c+CD103+ cell migration to the brain as mechanisms linking microbial colonization to behavioral changes in mice.

Opto-Myomatrix: μLED integrated microelectrode arrays for optogenetic activation and electrical recording in muscle tissue

This paper introduces Opto-Myomatrix, a device for optogenetic muscle activation and EMG recording, achieving high optical output and low electrode impedance.

B cell receptor dependent enhancement of dengue virus infection

This study shows that DENV infection enhances B cells via their BCR, linking ADE potential to B cell susceptibility and highlighting B cells as a key reservoir in immune-mediated DENV enhancement.

Comprehensive analysis of microbial content in whole-genome sequencing samples from The Cancer Genome Atlas project

The paper analyzes microbial content in 5,734 whole-genome sequencing samples from TCGA to provide a comprehensive reference dataset for future cancer microbiome studies.

Identifying and quantifying the contribution of maize plant traits to nitrogen uptake and use through plant modelling

This study quantifies how maize plant traits influence nitrogen uptake and use using a plant model, identifying key traits for breeding improved nitrogen use efficiency.

Inactivation of a non-canonical gp130 signaling arm attenuates chronic systemic inflammation and multimorbidity induced by a high-fat diet.

This study shows that inhibiting a non-canonical gp130 signaling pathway reduces chronic inflammation and multimorbidity in a high-fat diet model.

Non-viral Intron Knockins Enable Simplified and Flexible Targeting of Endogenous Genes

This paper introduces non-viral intron targeting to improve genetic editing flexibility and simplify cell selection by integrating synthetic exons into endogenous introns.

Unveiling the Intricate Sinking behavior of Large Diatoms: Insights from Time-Frequency Analysis of Palmerina hardmaniana Sinking under Silicate-Depleted Conditions

This study uses wavelet analysis to examine how silicate depletion affects the sinking behavior of Palmerina hardmaniana, revealing intermittent regulation with similar frequency ranges in control and stressed conditions.

Metabolic phenotyping of healthy and diseased human RPE cells

This study identifies nutrient utilization differences between healthy and diseased human RPE cells, showing reduced metabolic flexibility in SFD RPE and the impact of differentiation on nutrient use.

Ubiquitin-mediated stabilization of SlPsbS regulates low night temperature tolerance in tomatoes

This study identifies a ubiquitin-mediated degradation pathway involving SlCV and SlCSN5A that regulates SlPsbS stability under low night temperatures in tomatoes.

Identification and Structural Characterization of a mutant KRAS-G12V specific TCR restricted by HLA-A3

The paper identifies a TCR specific to KRAS-G12V neoantigen and characterizes its structural interaction with HLA-A3, revealing challenges in targeting this mutation.

INHBA/Activin A promotes tumor growth and induces resistance to anti-PD-L1 therapy by suppressing IFN-γ signaling

This study shows that INHBA/activin A suppresses IFN-γ signaling, leading to resistance to anti-PD-L1 therapy and promoting tumor growth.

Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants

This paper evaluates RQ3013, an mRNA vaccine against SARS-CoV-2 variants, showing robust immune responses and protection in animal models.

The Myc-Like Mlx Network Impacts Aging and Metabolism

This study shows that inactivating the Mlx network in mice accelerates aging-related phenotypes and increases cancer risk, similar to Myc inactivation, but with different lifespan outcomes.

A microfluidic platform with integrated porous membrane cell-substrate impedance spectroscopy (PM-ECIS) for biological barrier assessment

This paper introduces a microfluidic platform with PM-ECIS for assessing biological barriers, showing improved performance over traditional TEER methods in the presence of biomaterials and under flow conditions.

Dual Ethanolamine Head Groups in Ionizable Lipids Facilitate Phospholipid-free Stable Nanoparticle Formulation for Augmented and Safer mRNA Delivery

This paper introduces ionizable lipids with dual ethanolamine head groups for phospholipid-free mRNA delivery, showing improved stability, efficiency, and reduced toxicity.

Structural basis for the allosteric regulation and dynamic assembly of DNMT3B

This study determines the cryo-EM structure of DNMT3B under various oligomerization states, revealing how its domains interact to regulate its assembly and function.

Major data analysis errors invalidate cancer microbiome findings

The paper re-analyzes a cancer microbiome study and identifies two major data and methodological errors that invalidate its findings and those of subsequent studies.

Five inhibitory receptors display distinct vesicular distributions in T cells

The paper characterizes the subcellular distributions of five inhibitory receptors in T cells and finds they are distinct, with CTLA-4 preferentially associating with lysosomal-derived vesicles.

Recombinant outer membrane vesicles coupled with cytokines act as high-performance adjuvants against Helicobacter pylori infection in mice

This paper shows recombinant outer membrane vesicles with cytokines enhance immune responses and H. pylori clearance in mice compared to traditional adjuvants.

A mutation-mediated host shift drives Avian paramyxovirus type 1 evolution

This study identifies mutations in the P protein of Avian paramyxovirus type 1 that drive host shift from chickens to pigeons through enhanced degradation of LSm14A.

Discovery and characterization of highly potent and selective covalent inhibitors of SARS-CoV-2 PLpro

This study identifies and characterizes two covalent PLpro inhibitors, HUP0109 and DX-027, as potential treatments for SARS-CoV-2.

Structural insights into γH2Ax containing nucleosomes

The paper characterizes the interaction between MDC1 BRCT domains and γH2AX nucleosomes using cryo-EM, revealing structural insights into nucleosome stacking and its disruption by BRCT binding.

Vangl2 suppresses NF-κB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation

This study identifies Vangl2 as a negative regulator of NF-κB signaling in sepsis by promoting autophagic degradation of p65 through NDP52.

Antibody-mediated cell entry of SARS-CoV-2

This study shows that certain monoclonal antibodies can replace ACE2 to mediate SARS-CoV-2 entry into cells, indicating that ACE2 is not essential for viral infection.

Innate receptors with high specificity for HLA class I-peptide complexes

The paper identifies peptide-specific binding of KIR receptors to HLA class I complexes, revealing differences in specificity between inhibitory and activating KIRs.

Premature Aging and Reduced Cancer Incidence Associated with Near-Complete Body-Wide Myc Inactivation

This study investigates the effects of near-complete Myc inactivation in mice, finding premature aging features but reduced cancer incidence and linking Myc dysregulation to aging and cancer.

SARS-CoV-2 Mpro protease variants of concern display altered viral and host target processing but retain potency towards antivirals

The paper examines how SARS-CoV-2 Mpro variants affect viral and host protein processing but maintain antiviral potency.