Targeting BRPF3 moderately reverses olaparib resistance in high grade serous ovarian carcinoma
B. G. Bitler, T. M. Yamamoto, A. McMellen, H. Kim, Z. L. Watson
This study investigates the role of H3K14ac and associated proteins in PARPi resistance in HGSOC, finding that BRPF3 knockdown reduces resistance while HBO1 inhibition does not.
bioRxiv · Dec 21, 2021Cancer Biology