H. Kim

Redox-Triggered Coupling Network Mediates Long-Range Energy Trans-duction in Respiratory Complex I

The paper investigates the long-range energy transduction mechanism in Complex I using simulations and experiments, identifying key redox-triggered coupling sites.

Fragment Screening and Structure-Guided Development of Heparanase Inhibitors Reveals Orthosteric and Allosteric Inhibition

This study uses fragment-based drug design to identify novel heparanase inhibitors, resulting in compounds with improved potency for potential therapeutic applications.

Molecular principles of redox-coupled sodium pumping of the ancient Rnf machinery

This study elucidates the molecular mechanism of redox-coupled sodium pumping in the Rnf complex using cryo-EM, biochemical assays, and simulations.

Inhibiting monocyte migration reduces arterial thrombosis and facilitates thrombolysis

This study shows that inhibiting monocyte migration via CCR2 deficiency reduces arterial thrombosis and improves thrombolysis in mice.

IL-21 Shapes the B Cell Response in a Context-Dependent Manner

This study reveals that IL-21 regulates B cell fate through context-dependent effects on apoptosis and proliferation, using a conditional knock-out model and ex vivo cultures.

Protein-Induced Membrane Strain Drives Supercomplex Formation

This study shows that mitochondrial supercomplex formation reduces membrane strain and enhances allosteric crosstalk, with implications for OXPHOS efficiency.

The Mammalian KU70 C-terminus SAP Domain Is Required to Repair Exogenous DNA Damage

This study shows that the KU70 SAP domain is essential for repairing exogenous DNA damage but not for V(D)J recombination or development.

Spatially structured competition and cooperation alters algal carbon flow to bacteria

The paper investigates microbial interactions in algal systems, finding that cooperation, not just competition, significantly influences carbon flow from algae to bacteria.

Marginated neutrophils in the lungs effectively compete for nanoparticles targeted to the endothelium, serving as a part of the reticuloendothelial system

The paper shows that lung marginated neutrophils effectively uptake endothelial-targeted nanoparticles, suggesting they are part of the reticuloendothelial system.

Studies of infused megakaryocytes into mice support a ''catch-and release'' model of pulmonary-centric thrombopoiesis

The paper shows that megakaryocytes are entrapped in the lungs, release cytoplasmic fragments, and undergo platelet formation, supporting a pulmonary-centric 'catch-and-release' model of thrombopoiesis.

Pulmonary Fibrosis Ferret Model Demonstrates Sustained Fibrosis, Restrictive Physiology, and Aberrant Repair

This study shows that bleomycin-exposed ferrets develop sustained pulmonary fibrosis, restrictive lung physiology, and airway remodeling similar to human IPF.

Structural and functional analysis of the Nipah virus polymerase complex

This study determines the cryo-EM structure of the Nipah virus polymerase complex and identifies key domains critical for replication and transcription.

plantMASST - Community-driven chemotaxonomic digitization of plants

The paper curates LC-MS/MS data from plant extracts to create a taxonomically focused database for exploring plant-derived molecules.

Cholesterol Metabolite 27-Hydroxycholesterol Enhances the Secretion of Cancer Promoting Extracellular Vesicles by a Mitochondrial ROS-Induced Impairment of Lysosomal Function

This study shows that 27-hydroxycholesterol increases EV secretion by impairing lysosomal function through mitochondrial ROS, and antioxidant treatment reverses this effect.

Emergence of multiple foraging strategies under competition

The paper models how competition drives the evolution of multiple foraging strategies by balancing metabolic costs and foraging efficiency in a coevolutionary framework.

De novo design of protein minibinder agonists of TLR3

This study designs protein minibinders that act as agonists for TLR3, showing nanomolar binding and biological activity in cell lines.

Mosaic display of stable hemagglutinin monomers induces broad immune responses

This study develops a nanoparticle vaccine displaying conserved influenza HA epitopes, inducing broad neutralizing antibodies against multiple viral subtypes.

rRNA Operon Improves Species-Level Classification of Bacteria and Microbial Community Analysis Compared to 16S rRNA

This study compares the accuracy of species-level classification and microbial community analysis using rRNA operon versus 16S rRNA gene and V3-V4 regions, finding the rRNA operon more accurate.

OCA-B/Pou2af1 is sufficient to promote CD4+ T cell memory and prospectively identifies memory precursors

This study shows that OCA-B expression promotes CD4+ T cell memory and identifies memory precursor cells using a reporter mouse line.

In-situ microscopy-assisted meniscus-guided coating for highly sensitive reduced graphene oxide-based nanocomposite biosensor

The paper develops a meniscus-guided coating technique using in-situ microscopy and CFD modeling to create high-performance rGO-based biosensors with picomolar detection limits.

Journey to the center of the phage; revealing the ejectosome of Pectobacterium bacteriophage {Phi}M1

This paper determines the cryo-EM structure of the ejectosome of bacteriophage {Phi}M1, revealing unique structural features and a novel DNA spooling mechanism.

FABP4 as a Therapeutic Host Target Controlling SARS-CoV2 Infection

This study identifies FABP4 as a host target that modulates SARS-CoV-2 infection, showing that its inhibition reduces viral replication and lung damage in infected hamsters.

Stress relaxing granular bioprinting materials enable complex and uniform organoid self-organization

This paper introduces a tunable granular biomaterial, MAGIC matrix, that enables precise control of initial conditions for tissue growth, leading to improved organoid reproducibility and complexity.

Chronic Pod-Mod E-Cigarette Aerosol Exposure Induces Aortic Dysfunction in Hypercholesterolemic Mice: Role of Oxidative Stress and Inflammation

Nuclear pores as conduits for fluid flow during osmotic stress

This study shows that Dictyostelium discoideum uses nuclear pores as conduits for fluid flow during osmotic stress, distinct from passive diffusion and active transport.

Discovery of Highly Active Kynureninases for Cancer Immunotherapy through Protein Language Model

The paper identifies and validates four kynureninases using homology searches and protein language models, with the most active one showing significant tumor reduction in mouse models.

Single-cell transcriptional mapping reveals genetic and non-genetic determinants of aberrant differentiation in AML

The paper constructs a reference atlas of human hematopoiesis and maps AML differentiation patterns, revealing genetic and non-genetic factors driving aberrant differentiation in leukemia.

Genomic hypomethylation in cell-free DNA predicts responses to checkpoint blockade in lung and breast cancer

This study develops iMethyl, a method to estimate genomic hypomethylation from cell-free DNA to predict responses to immune checkpoint blockade in cancer patients.

An RXLR effector targets ER-Golgi interface to induce ER stress and necrotic cell death

This study identifies Pc12, an RXLR effector from P. capsici, which induces necrotic cell death by disrupting ER-Golgi trafficking through interaction with Rab13-2.

Tertiary-interaction characters enable fast, model-based structural phylogenetics beyond the twilight zone

This paper uses tertiary-interaction characters to improve structural phylogenetics beyond the twilight zone, achieving accurate results with fast computation.