Chemical degradation of BTK/TEC as a novel approach to inhibit platelet function and thrombosis.
J. S. Trory, A. Munkacsi, K. Sledz, L. J. Goudswaard, K. J. Heesom, S. F. Moore, B. Nabet, V. K. Aggarwal, I. Hers
This study shows that chemical degradation of BTK/TEC in human platelets reduces thrombotic function without affecting PAR-1-mediated responses.
bioRxiv · May 30, 2022 · PreprintCell Biology